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Synthesis and Spectroscopic Investigations of Four New Y(Ⅲ), Ge(Ⅳ), W(Ⅵ) and Si(Ⅳ) Penicillin Antibiotic Drug Complexes

Synthesis and Spectroscopic Investigations of Four New Y(Ⅲ), Ge(Ⅳ), W(Ⅵ) and Si(Ⅳ) Penicillin Antibiotic Drug Complexes

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Abstract

A four new penicillinate complexes were prepared through the chemical interactions of penicillin potassium salt (Pin) with YCl3, GeCl4, WCl6 and SiCl4 metal ions. These metal complexes were characterized using spectroscopic techniques (e.g. 1H-NMR, infrared, electronic UV-Vis) as well as elemental, conductivity, and magnetic measurements. The molar conductance values were highly, showing their electrolytic nature. The magnetic and electronic study strongly recommends the octahedral geometry of all penicillinate complexes. A monomeric structures of Pin complexes are proposed with octahedral coordinated metals ions. The metal ions are coordinated toward Pin as tridentate ligand through the amide and β-lactam carbonyls and a carboxylate group from penicillin. The in vitro antimicrobial activity of all the complexes, at concentrations in μg·mL-1, was screened against four bacterial pathogens, namely, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus, and two kinds of fungi Aspergillus flavus and Candida albicans showed better activity compared to parent drug and control drug. The anti-cancer inhibition of the tungsten(Ⅵ) complex was assessed against the human hepato cellular carcinoma (HepG-2) tumor cell line with IC50 value is 646 μg·mL-1.

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中图分类号:O6573

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收稿日期:2018-12-21

修改稿日期:2019-03-04

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Abeer A. El-Habeeb:College of Science, Princess Nourah Bint Abdulrahman University, Department of Chemistry, Riyadh 11671, Saudi Arabia
Moamen S. Refat:Chemistry Department, Faculty of Science, Taif University, P.O. Box 888, Al-Hawiah, Taif 21974, Saudi ArabiaDepartment of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt

联系人作者:Moamen S. Refat(msrefat@yahoo.comIntroduction)

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引用该论文

Abeer A. El-Habeeb,Moamen S. Refat. Synthesis and Spectroscopic Investigations of Four New Y(Ⅲ), Ge(Ⅳ), W(Ⅵ) and Si(Ⅳ) Penicillin Antibiotic Drug Complexes[J]. Spectroscopy and Spectral Analysis, 2019, 39(9): 2982-2988

Abeer A。 El-Habeeb,Moamen S。 Refat。 Synthesis and Spectroscopic Investigations of Four New Y(Ⅲ), Ge(Ⅳ), W(Ⅵ) and Si(Ⅳ) Penicillin Antibiotic Drug Complexes[J]。 光谱学与光谱分析, 2019, 39(9): 2982-2988

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