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PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy

PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy

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Abstract

The photosensitizer (PS) as photodynamic therapy (PDT) agent, can also serve as the contrast agent for dual-modal fluorescence imaging (FLI) and photoacoustic imaging (PAI) for precise cancer theranostics。 In this study, the PAI capability of commercial PS, benzoporphyrin derivative monoacid ring-A (BPD) were examined and compared with that from the other PSs and dyes such as TPPS4, Cy5 dye and ICG。 We discovered that BPD exhibited its advantage as contrast agent for PAI。 Meanwhile, BPD can also serve as the contrast agent for enhanced FLI。 In particular, the PEGylated nanoliposome (PNL) encapsulated BPD (LBPD) was produced for contrast enhanced dual-modal FLI and PAI and imaging-guided high-e±ciency PDT。 Enhanced FLI and PAI results demonstrated the signiˉcant accumulation of LBPD both within and among individual tumor during 24 h monitoring for in vivo experiment tests。 In-vitro and in-vivo PDT tests were also performed, which showed that LBPD have higher PDT e±ciency and can easily break the blood vessel of tumor tissues as compared to that from BPD。 It was discovered that LBPD has great potentials as a diagnosis and treatment agent for dual-modal FLI and PAI-guided PDT of cancer。

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基金项目:supported by the National Basic Research Program of China (2015CB352005), the National Natural Science Foundation of China (61705139, 61875135, 61525503, 61620106016, 61835009, 81727804), Guangdong Natural Science Foundation Innovation Team (2014A030312008, 2017A030310136), Shenzhen Basic Research Project (JCYJ20150930104948169, JCYJ20160328144 746940, GJHZ20160226202139185, JCYJ2017041 2105003520, JCYJ20170817094735945, JCYJ201 70818090620324), China and Postdoctoral Science Foundation (2017M612724), China. This study was also supported by MYRG2016-00110-FHS and MYRG grants from the University of Macau in Macau, and FDCT 0011/2018/A1 and FDCT 025/2015/A1 grants from Macao government.

收稿日期:2018-12-03

修改稿日期:2019-03-20

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Hao Xu:College of Optoelectronic Engineering, Shenzhen University, Key Laboratory of Optoelectronic, Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen, Guangdong, P. R. ChinaFaculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, P. R. China
Yubin Liu:Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, P. R. China
Junle Qu:College of Optoelectronic Engineering, Shenzhen University, Key Laboratory of Optoelectronic, Devices and Systems of Ministry of Education and Guangdong Province, Shenzhen, Guangdong, P. R. China
Zhen Yuan:Faculty of Health Sciences, University of Macau, Taipa, Macau SAR 999078, P. R. China

联系人作者:Junle Qu(jlqu@szu.edu.cn)

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引用该论文

Hao Xu,Yubin Liu,Junle Qu,Zhen Yuan. PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy[J]. Journal of Innovative Optical Health Sciences, 2019, 12(3): 1941003

Hao Xu,Yubin Liu,Junle Qu,Zhen Yuan。 PEGylated liposomal photosensitizers as theranostic agents for dual-modal photoacoustic and fluorescence imaging-guided photodynamic therapy[J]。 Journal of Innovative Optical Health Sciences, 2019, 12(3): 1941003

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